subcommissural organs การใช้

• So, the subcommissural organ appeared to be unique showing neither GLUT1 nor capillary.
• Subcommissural organ-spondin is a  giant ( 5000 amino acids ) glycoprotein ( thrombospondin superfamily ) found in axonal pathfinding molecules.
• This finding implies that the subcommissural organ and its associated Reissner's fibers are an integral part of fluid electrolyte balance and water homeostasis.
• One of the proteins, secreted by the subcommissural organ and expressed in the central nervous system, present in the Reissner s fiber is spondin.
• The subcommissural organ ( SCO ) is a small secretory organ located near the anterior entrance of the cerebral aqueduct and at the midline roof of the third ventricle.
• While the function of the subcommissural organ is still under investigation, it has been hypothesized that it is also part of the mechanism of aldosterone secretion and CSF detoxification, along with osmoregulation.
• Given that the subcommissural organ is not highly permeable and does not possess presenilin-1 or the lack of huntingtin in wnt cell lineages leads to congenital hydrocephalus, which highlights the role of these proteins mediating the relation between the SCO and the condition.
• The ependymal cell bodies present a clear zonation, specially marked in certain species : the perinuclear region-the most distinct ultrastructural feature off virtually all species is the presence of large and dilated cisternae of the rough endoplasmic reticulum ( RER ); intermediate region  constituted mainly by the RER and the Golgi apparatus ( it is not certain the involvement of the Golgi apparatus in the secretary process of the subcommissural organ ); subapical region  short region, with microtubules, mitochondria and smooth endoplasmic reticulum; and an apical region  projecting a large protrusion into the ventricle.